PEBC Neurology — Parkinson & Seizure Pharmacotherapy

20 cards

• A 68-year-old with Parkinson disease has bradykinesia, rigidity, and difficulty initiating movement. Symptoms impair daily function. Which treatment provides the greatest symptomatic motor benefit?
• A patient taking levodopa experiences nausea and hypotension due to peripheral conversion of levodopa to dopamine. What is the purpose of adding carbidopa?
• A patient with Parkinson disease has predictable end-of-dose wearing-off despite levodopa. Which add-on class prolongs levodopa effect by inhibiting peripheral levodopa metabolism?
• A patient with Parkinson disease develops wearing-off. The team wants to inhibit central and peripheral MAO-B-mediated dopamine breakdown. Which drugs are options?
• A patient with Parkinson disease has dyskinesia associated with levodopa. Which drug can reduce dyskinesia by antagonizing NMDA receptors?

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